Summary Alzheimer’s is a disease of slowly fading cognition. If you would ask me how much my grandmother’s Alzheimer’s progressed over...

Summary BioVie always argued that it saw a correlation between effects on cognition and reduction of TNF levels. That TNF reduction...

Introduction Amyloid beta has been the primary hallmark of Alzheimer’s disease for years. On the one hand, numerous trials focusing on...

Introduction Science journalist Charles Piller wrote a book, called ‘Doctored: fraud, arrogance, and tragedy in the quest to cure...

Introduction For years, the scientific focus may have been too focused on targeting amyloid, while inflammation and modulation of glial...

Summary INmune Bio is making significant strides across multiple programs, positioning itself as a major player in biotech. CORDstrom...

Summary Coverage of the Alzheimer’s space would be incomplete without a blog post on Cassava Sciences. Now was the right time. Cassava...

On JLO, RFK, the NIH, TNF, Karl Herrup and innovation - a longer post.   Summary The amyloid hypothesis did not yield the desired...

Summary I had a call with some investors earlier this week. During the call, the theme of accelerated approval came up. I had done a blog...

Historical failure rate of therapies targeting amyloid Alzheimer’s is characterized by aggregation of anti-amyloid antibodies and...

Introduction I am picking up my previous work to assess the Alzheimer’s space today, with a particular focus on INmune Bio, as the...

Summary APOE4, involved in different mechanisms in the brain including lipid homeostasis, is the strongest risk factor for Alzheimer’s...

Summary The evolution of the treatment failures for Parkinson’s disease has striking similarities with Alzheimer’s. Just like in...

Summary Neurofilament Light (NfL) is potentially the most important biomarker in neurodegenerative diseases. The FDA’s AdCom validated...

Summary Allostatic load is the cumulative burden of stressors one encounters throughout life. The underlying causes/triggers for any...

A book review with some notes on my recent research, part I Introduction I have stated before that I believe that the field of psychiatry...

Introduction For some time now, INmune Bio has been announcing their trial in treatment resistant depression (TRD). The market, either...

Summary: · The detrimental action of glia, mostly microglia, in the inflamed brain is the last piece of the scientific puzzle; · ...

The 7 April 2022 CMS decision denying Aduhelm medicare coverage On 7 April 2022, the Centers for Medicare and Medicaid Services (CMS)...

"I think a good drug might fail in a clinical trial because not all the subjects have the same kind of Alzheimer's. Shubhabrata...