Historical failure rate of therapies targeting amyloid Alzheimer’s is characterized by aggregation of anti-amyloid antibodies and...

Introduction I am picking up my previous work to assess the Alzheimer’s space today, with a particular focus on INmune Bio, as the...

Summary APOE4, involved in different mechanisms in the brain including lipid homeostasis, is the strongest risk factor for Alzheimer’s...

Summary The evolution of the treatment failures for Parkinson’s disease has striking similarities with Alzheimer’s. Just like in...

Summary Neurofilament Light (NfL) is potentially the most important biomarker in neurodegenerative diseases. The FDA’s AdCom validated...

Summary Allostatic load is the cumulative burden of stressors one encounters throughout life. The underlying causes/triggers for any...

A book review with some notes on my recent research, part I Introduction I have stated before that I believe that the field of psychiatry...

Introduction For some time now, INmune Bio has been announcing their trial in treatment resistant depression (TRD). The market, either...

Summary: · The detrimental action of glia, mostly microglia, in the inflamed brain is the last piece of the scientific puzzle; · ...

The 7 April 2022 CMS decision denying Aduhelm medicare coverage On 7 April 2022, the Centers for Medicare and Medicaid Services (CMS)...

"I think a good drug might fail in a clinical trial because not all the subjects have the same kind of Alzheimer's. Shubhabrata...

Introduction CJ Barnum, head of neuroscience at INMB, has a talent for translating his superior scientific knowledge to a crowd. The...

Introduction Apart from the abundant preclinical data showing efficacy in animals, XPro has been tested in six patients in the Phase 1...

What is neurofilament-light chain (NfL)? Neurofilaments, the larger group to which NfL belongs, are structural components of neuronal...

A small recap of existing drugs approved for AD There are four FDA-approved drugs for Alzheimer’s disease, three of which are...

What most investors seem to forget is diving into scientific literature The trials and tribulations of the stock market seem, to me, in...

Reminder of the NK cell activation threshold as a predictor of survival This, we know. · INKmune generates memory-like NK cells in...

Summary: INKmune is an NK-targeting immuno-oncology drug allowing treatment in a wide range of NK-related cancers; INKmune’s production...

In my mind's eye, these stairs keep on going into 2023 and the years after. INTRODUCTION The previous five blogs have laid out the...

My views on possible partnership/buyout and valuation of INMB will be set out below. The highlights are the following. - I consider a...